Successful discrimination of tiny numerical differences

Successful discrimination of protein interactions.

We present results from the prediction of protein complexes associated with the first Critical Assessment of PRediction of Interactions (CAPRI) experiment. Our algorithm, SmoothDock, comprises four steps: (1) we perform rigid body docking using the program DOT, keeping the top 20,000 structures as ranked by surface complementarity; (2) we rerank these structures according to a free energy estim...

3 Discrimination of Sound Differences

Successful removal of a ruptured silastic percutaneous central venous catheter in a tiny premature infant.

The spontaneous rupture of a Silastic catheter is a rare occurrence. We describe our experience of managing a tiny premature infant with embolization of a Silastic percutaneous central venous catheter (PCVC) and discuss the possible mechanisms of the embolization. A 28-week, 980 g, preterm male infant received a Silastic PCVC (Epicutaneo Cava Catheter, Vygon, Germany) for parenteral nutritional...

Hemispheric differences in avian song discrimination.

Auditory input to the right or left forebrain of adult male zebra finches (Taeniopygia guttata) was disrupted by lesioning the ipsilateral auditory relay nucleus of the thalamus. These birds were then presented with two kinds of auditory discriminations: (i) between their own song and the song of a cage mate; (ii) between two versions of an unfamiliar zebra finch song that differed only in the ...

Tiny dancers

A vital step in growth factor-driven angiogenesis is the coordinated engagement of endothelial integrins with the extracellular matrix. The molecular mechanisms that partner growth factors and integrins are being elucidated, revealing an intricate interaction of surface receptors and their signaling pathways.